WAY 120,491 activates ATP-sensitive potassium channels in rat tail artery

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WAY 120,491 activates ATP-sensitive potassium channels in rat tail artery.

WAY 120,491 lowers blood pressure in a number of animal models. Its mechanism of action appears to be the selective opening of K+ channels in vascular smooth muscle cells. The patch clamp technique was used to determine the specific K+ channel affected by WAY 120,491 in isolated tail artery cells of the rat. In the inside-out configuration, WAY 120,491 caused a dose dependent partial reversal o...

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ژورنال

عنوان ژورنال: European Journal of Pharmacology

سال: 1992

ISSN: 0014-2999

DOI: 10.1016/0014-2999(92)94841-i